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Indications And Clinical Uses: The short-term relief of manifestations of excessive anxiety in patients with anxiety neurosis.
Adjunct for the relief of excessive anxiety that might be present prior to surgical procedures.
Lorazepam may be given by injection in situations where a rapid effect is needed to control a manic episode or a panic attack.
Lorazepam helps with sleeping difficulties associated with anxiety by reducing the time you take to fall asleep and the number of times you wake up in the night, as well as increasing the total amount of time spent sleeping.
Because of the lack of sufficient clinical experience lorazepam injection is not recommended for use in patients less than 18 years of age.
Clinical trials have shown that patients over the age of 50 years may have a more profound and prolonged sedation with i.v. Ordinarily an initial dose of 2 mg may be adequate, unless a greater degree of lack of recall is desired.
Lorazepam has also been shown to possess anticonvulsant activity.
Peak plasma concentrations of free lorazepam after oral administration are reached at 2 hours (range 1 to 6 hours).
Neurotransmitters are chemicals that are stored in nerve cells in the brain and nervous system and are involved in transmitting messages between the nerve cells.
It also helps with related symptoms, such as acute mania, excitement or agitation that may occur in psychiatric illnesses, such as bipolar affective disorder.
In bipolar disorder benzodiazepines help calm the individual while the main medicines for this condition (mood stabilisers) begin to take effect.
Therefore, patients should be warned against engaging in hazardous activities requiring mental alertness and motor coordination, such as operating dangerous machinery or driving motor vehicles. use, lorazepam injection should be diluted with an equal amount of compatible diluent (see Dosage). Care should be taken to determine that any injection will not be intraarterial and that perivascular extravasation will not take place. lorazepam, when given alone in greater than the recommended dose, or at the recommended dose and accompanied by other drugs used during the administration of anesthesia, may produce heavy sedation; therefore, equipment necessary to maintain a patent airway and to support respiration/ventilation should be available.
Partial airway obstruction may occur in heavily sedated patients. As with any premedicant, extreme care must be used in administering lorazepam injection to elderly or very ill patients and to those with limited pulmonary reserve, because of the possibility that apnea and/or cardiac arrest may occur.